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Maintenance fluids should not be used. Drug: Early Vasopressors Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure MAP between 65 mmHg and 75 mmHg. Liberal Fluids The general approach is to use fluid boluses to treat hypotension. Administer ml fluid boluses for fluid triggers until 5 liters administered or development of clinical s of acute volume overload develop. Any type of isotonic crystalloid normal saline, ringers lactate, balanced solution such as plasmalyte is permitted. Any day that a patient is alive and without organ support will represent days alive and free of organ support.

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Participants who do not survive to day 28 are ased zero ventilator-free days. Patients with chronic renal replacement therapy initiated prior to the current sepsis illness will not be eligible to meet this endpoint. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Patients who died prior to day 28 are ased zero vasopressor free days.

Patients who died prior to day 28 are ased zero renal replacement free days. To learn more about liebral study, you or your doctor may contact the study research staff using the contacts provided below. Any day that a patient is alive and without organ support will represent days alive and free of organ support.

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Drug: Early Vasopressors Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure Frree between 65 mmHg and 75 mmHg. Maintenance fluids should not be used. If a value is not available at baseline, it will be assumed to be normal.

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Any type of isotonic crystalloid normal saline, ringers lactate, balanced solution such as plasmalyte is permitted. If a patient was on renal replacement therapy prior to presentation, then the renal dysfunction component to the SOFA score will be omitted as well.

Talk with your doctor and family members or friends about deciding to a study. Liberal Fluids The general approach is to use fluid boluses to treat hypotension.

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If a patient was on renal replacement therapy prior to presentation, then the renal dysfunction component to the SOFA score will be omitted as well. Any day that a patient is alive and without organ support will represent days alive and free of organ support.

For general information, Learn About Clinical Studies. Non-invasive mechanical ventilation will not be included as an outcome.

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Non-invasive mechanical ventilation will not be included as an fee. Patients with chronic renal replacement therapy initiated prior to the current sepsis illness will not be eligible to meet this endpoint. At the 72 hours assessment, if a value is missing then we will carry forward the closet ly known value. Participants who do not survive to day 28 are ased zero ventilator-free days. If a patient is intubated or heavily sedated at either 0 or 72 ssex, the GCS will be omitted when calculating the change in score.

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Administer ml fluid boluses for fluid triggers until 5 liters administered or development of clinical s of acute volume overload develop. Talk with your doctor and family members or friends about deciding to a study. Maintenance fluids should not be used. This is a binary outcome.

Patients on chronic renal replacement therapy will not be eligible for this endpoint determination. Patients on chronic renal replacement therapy will not be eligible for this endpoint determination.

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Patients who die on or prior to day 28 are ased zero hospital free days. This is a binary outcome. Liberal Fluids The general approach is to use fluid boluses to treat hypotension. Textt Early Vasopressors Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure MAP between 65 mmHg and 75 mmHg.

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Administer ml fluid boluses for fluid triggers until 5 liters administered or development of clinical s of acute volume overload develop. If a patient is intubated or heavily sedated at either 0 or 72 hours, the GCS will libera, omitted when calculating the change in score. Any type of isotonic crystalloid normal saline, ringers lactate, balanced solution such as plasmalyte is permitted.

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Patients who died prior to day 28 are tet zero renal replacement free days. If a value is not available at baseline, it will be assumed to be normal. Patients who die on or prior to day 28 are ased zero hospital free days.